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Monitoring vital signs closely after medication administration when an allergic reaction is suspected is crucial because vital signs provide immediate insight into the patient's physiological response. An allergic reaction can lead to significant changes in vital signs; for instance, a rapid decrease in blood pressure or an increase in heart rate can indicate a severe reaction, such as anaphylaxis. Additionally, changes in respiratory rate may suggest airway compromise, which is a life-threatening condition.

While observing for changes in skin condition is also important, it primarily focuses on dermatological symptoms, which may not give a comprehensive understanding of the overall impact of the allergic reaction. Administering an oral antihistamine is a potential treatment for milder reactions but may not address the immediate assessment needs or the status of the patient. Checking for bleeding is typically not directly related to allergic reactions unless there is a specific concern related to the medication's side effects or interactions. Therefore, closely monitoring vital signs is essential for timely and effective intervention in cases of allergic reactions.